Publications 2012 


  • St-Pierre, C.;  Ouellet, M.; Giguère, D.; Ohtake, R.; Roy, R.; Sato, S.; Tremblay, M.J. Galectin-1-Specific Inhibitors as a New Class of Compounds To Treat HIV-1 Infection, Antimicrobial Agents and Chemotherapy, 2012, 56, 154-162.

  • A.; Arnold, A.A.; Genard, B.; Nadalini, J.B.; Séguin Heine, M.O.; Marcotte, I.; Tremblay, R.; Sleno, L. Determination of isotopic labeling of proteins by precursor ion scanning liquid chromatography/tandem mass spectrometry of derivatized amino acids applied to nuclear magnetic resonance studies.Rapid Communications in Mass Spectrometry, 2012, 26, 1165-1174.


Publications 2011  

  • Chabre, Y. M.; Giguère, D.; Blanchard, B.; Rodrigue, J.; Rocheleau, S.; Neault, M.; Rauthu, S.; Papadopoulos, A.; Arnold, A.; Imberty, A.; Roy, R. Design, synthesis and binding properties of mono- and multivalent stable C-galactosides to Pseudomonas aeruginosa PA-IL. Chem. Eur. J. 2011, 17, 6545-6562.



    Giguère, D.; André, S.; Bonin, M.-A.; Bellefleur, M.A.; Provencal, A.; Cloutier, Pucci,; Roy, R.; Gabius, H.-J. Inhibitory potential of chemical substitutions at bioinspired sites of β-D-galactopyranoside on glycoprotein/cell surface binding of two classes of medically relevant lectins. Bioorg. Med. Chem. 2011, 19, 3280-3287. 

  • Souryvanh Nirasay, Yves Mouget, Isabelle Marcotte, Jerome P. Claverie Supported bilayer on a nanopatterned membrane as model PAMPA membranes. International Journal of Pharmaceutics, Volume 421, 170-175. 

  • Chabre, Y.M.; Brisebois, P.P.;  Abbassi, L.; Sheena C. Kerr, S.C.; Fahy, J.V.; Marcotte, I.; Roy, R. Hexaphenylbenzene as a Rigid Template for the Straightforward Syntheses of “Star-Shaped” Glycodendrimers, J. Org. Chem, 2011, 76, 724-727.

  • Byette, F.; Bouchard, F.; Pellerin, C.; Paquin, J.; Marcotte, I.; Mateescu, M.A. Cell-culture compatible silk fibroin scaffolds concomitantly patterned by freezing conditions and salt concentration, Polym. Bull. 2011, 67, 159-175.
  • Gosline, S.J.; Nascimento, M.; McCall, L.I.; Zilberstein, D.; Thomas, D.Y.; Matlashewski, G.; Hallett, M. 2011 Intracellular eukaryotic parasites have a distinct unfolded protein response. PLoS One. Apr 29;6(4):e19118.
  • DE Warschawski*, AA Arnold, M Beaugrand, A Gravel, E Chartrand, & I Marcotte* (2011) Choosing membrane mimetics for structural studies of transmembrane proteins. Biochim. Biophys. Acta 1808, 1957-1974.


Publications 2010  

  • André, S.; Giguère, D.; Dam, T. K.; Brewer, C. F.; Gabius, Hans-Joachim; Roy, R. O/S-Glycosides with aglyconic extensions at the anomeric position: synthesis and novel HTS screening for inhibitory activity on medically relevant galactoside-specific lectins in assays of increasing biorelevance. New J. Chem. 2010, 34, 2229 - 2240.
  • Lameignere, E.; Shiao, T. C.; Roy, R.; Wimmerova, M.; Dubreuil, F.; Varrot, A.; Imberty, A. Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin. Glycobiology, 2010, 20, 87-98.
  • G Larocque, AA Arnold, É Chartrand, Y Mouget & I Marcotte* (2010) Effect of Sodium Bicarbonate as a Pharmaceutical Formulation Excipient on the Interaction of Fluvastatin with Membrane Phospholipids. Eur. Biophys. J. 39; 1637-1647.
  •  De Koninck P., Archambault D, Hamel F., Sarhan F, Mateescu M.A.  - Carboxymethyl Starch Excipients for gastrointestinal stable oral protein formulation containing protease inhibitors.  J. Pharm. Pharmaceut. Sci. 2010, 13, 58-70
  • Ducharme P, Maltais D, Desroches D, Mateescu M A, Paquin J : Ceruloplasmin-induced aggregation of P19 neurons involves a serine protease activity and is accompanied by reelin cleavage. Neuroscience 2010, 167, 633-643
  • Pekka Maattanen, Kalle Gehring, John J.M. Bergeron and David Y Thomas (2010) Protein Quality control in the ER: the recognition of misfolded proteins. Seminars in Cell Dev Biol. 21: 500-511. Invited Review 
  • Kozlov, Guennadi, Määttänen, Pekka, Thomas, David Y., Gehring, Kalle (2010) Structure of the catalytic a0a fragment of the protein disulfide isomerase ERp72. J. Mol. Biol. 401: 618-625.
  • Guennadi Kozlov and Pekka Maattanen, David Y Thomas and Kalle Gehring (2010) A structural overview of the PDI family of proteins. FEBS Journal 277: 3924-3936 (Invited review)
  • Kozlov, G., Bastos-Aristizabal, S., Määttänen, P., Rosenauer, A., Zheng, F., Killikelly, A., Trempe, J.F.; Thomas, D.Y. & Gehring, K. Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain, J. Mol. Biol. 2010, 285, 35551-35557.
  • Epp, E., G. Vanier, D. Harcus, A. Y. Lee, G. Jansen, M. Hallett, D. Sheppard, D. Y. Thomas, C. Munro, A. Mullick, M. Whiteway Reverse Genetics in Candida albicans that Reveals ARF Cycling is Essential for Drug Resistance and Virulence. PLoS Pathogens 6:e1000753 (2010) 
  • Elizabeth Tahanian, Simon Lord-Dufour, Abhirup Das, Chaitan Khosla, Rene Roy, and Borhane Annabi, (2010) Inhibition of Tubulogenesis and of Carcinogen-mediated Signaling in Brain Endothelial Cells Highlight the Antiangiogenic Properties of a Mumbaistatin Analog, Chem Biol Drug Des 2010; 75: 481–488.
  • Ngoumfo, R. M.; Jouda, J.-B.; Mouafo, F. T.; Komguem, J.; Mbazoa, C. D.; Shiao, T. C.; Choudhary, M. I.; Laatsch, H.; Legault, J.; Pichette, A.; Roy, R. In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr. Bioorg. Med. Chem. 2010, Bioorg. Med. Chem. 2010, 18, 3601-3605
  • LeBlanc, A., Shiao, T. C.;  Roy, R., Sleno L., Improved detection of reactive metabolites with bromine-containing glutathione analog using mass defect and isotope pattern matching. Rapid Comm. Mass Spectrom. 2010, 24, 1241-50.
  • É Chartrand, AA Arnold, A Gravel, S Jenna & I Marcotte (2010) Potential Role of the Membrane in the hERG Channel Functioning and Long QT Syndrome, Submitted to Biochim. Biochim. Biophys. Acta 1798, 2010 1651-1662.

  • Lee A.Y., Perrault R., Harel S., Boulier E., Suderman M., Hallett M.T. and Jenna S. * (2010) Searching for signaling balance through the identification of genetic interactors of the Rab Guanine-nucleotide Dissociation Inhibitor, gdi-1. PLoS One. 13, 5, e1062

Publications 2009

  • Denisov, A.Y., Määttänen, P., Dabrowski, C., Kozlov, G., Thomas, D.Y. & Gehring, K. (2009) “Solution structure of the bb' domains of human protein disulfide isomerase.” FEBS J. 276(5):1440-1449. (CIHR MOP-74567)

  • Kozlov, G., Määttänen, P., Schrag, J.D., Hura, G.L., Gabrielli, L., Cygler, M., Thomas, D.Y. & Gehring K. (2009) “Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72”, Structure 17(5):651-659. (CIHR MOP-74567)

  • Borhane Annabi, Marie-Paule Lachambre, Karine Plouffe, Robert Moumdjian, Richard Béliveau: Propranolol adrenergic blockade inhibits human brain endothelial cells tubulogenis and matrix metalloproteinase-9-secretion. Pharmacological Research 60 (2009) 438 -445

Publications 2008

  • Fortier, S.; Touaibia, M.; Roy, R., Annabi, B. Inhibition of cell surface clustering effects of Concanavalin-A by tetra- and hexavalent mannosides : Impact on MT1-MMP-mediated proMMP-2 activation and cell death signaling in marrow stromal cells. Glycobiology, 2008, 18, 195-204.

  • Giguère, D.; Bonin, M.-A.; Cloutier, P.; Patnam, R.; St-Pierre, C.; Sato, S.; Roy, R. Syntheis of Stable and Selective Inhibitors of Human Galectin-1 and -3. Bioorg. Med. Chem., 2008, 16, 7811–7823. 

  • Simon Fortier, Mohamed Touaibia , Simon Lord-Dufour, Jacques Galipeau, René Roy , and Borhane Annabi, (2008) Tetra- and hexavalent mannosides inhibit the pro-apoptotic, antiproliferative and cell surface clustering effects of concanavalin-A: Impact on MT1-MMP functions in marrow-derived mesenchymal stromal cells, Glycobiology vol. 18 no. 2 pp. 195–204, 2008.


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Lee A.Y., Perrault R., Harel S., Boulier E., Suderman M., Hallett M.T. and Jenna S.* (2010) Searching for signaling balance through the identification of genetic interactors of the Rab Guanine-nucleotide Dissociation Inhibitor, gdi-1. PLoS One. 13;5(5):e10624